Journal article
Mallory A Kisner, Lauren A Sussman, Thushini Manuweera, E. Grodin, Samantha J. Fede, J. Sarlls, R. Momenan
Alcoholism, clinical and experimental research, 2021
Alcoholism, clinical and experimental research, 2021
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APA
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Kisner, M. A., Sussman, L. A., Manuweera, T., Grodin, E., Fede, S. J., Sarlls, J., & Momenan, R. (2021). Evaluating effects of sex and age on white matter microstructural alterations in alcohol use disorder: A diffusion tensor imaging study. Alcoholism, Clinical and Experimental Research.
Chicago/Turabian
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Kisner, Mallory A, Lauren A Sussman, Thushini Manuweera, E. Grodin, Samantha J. Fede, J. Sarlls, and R. Momenan. “Evaluating Effects of Sex and Age on White Matter Microstructural Alterations in Alcohol Use Disorder: A Diffusion Tensor Imaging Study.” Alcoholism, clinical and experimental research (2021).
MLA
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Kisner, Mallory A., et al. “Evaluating Effects of Sex and Age on White Matter Microstructural Alterations in Alcohol Use Disorder: A Diffusion Tensor Imaging Study.” Alcoholism, Clinical and Experimental Research, 2021.
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@article{mallory2021a,
title = {Evaluating effects of sex and age on white matter microstructural alterations in alcohol use disorder: A diffusion tensor imaging study.},
year = {2021},
journal = {Alcoholism, clinical and experimental research},
author = {Kisner, Mallory A and Sussman, Lauren A and Manuweera, Thushini and Grodin, E. and Fede, Samantha J. and Sarlls, J. and Momenan, R.}
}
Abstract
BACKGROUND The alterations in white matter microstructure associated with chronic alcohol use have been demonstrated by previous diffusion tensor imaging (DTI) research. However, there is conflicting evidence as to whether such differences are influenced by an individual's biological sex. The purpose of the present study was to investigate the prevalence of sex differences in the white matter microstructure of the brains of individuals with alcohol use disorder (AUD) and healthy controls.
METHODS One hundred participants with AUD (38 female, ages 21-68) partaking in the NIAAA's inpatient treatment program and 98 healthy control participants (52 female) underwent a diffusion-weighted scan. Images collected were processed for each subject individually and voxelwise tract-based spatial statistics (TBSS) analysis was conducted to measure differences in the DTI measures of fractional anisotropy (FA), axial diffusivity (AD), and radial diffusivity (RD).
RESULTS A 2-way between-subjects ANCOVA testing for differences in group and sex revealed widespread differences between AUD and control subjects, but no interaction between group and sex. Additional analyses exploring demographic and alcohol use variables showed significant impacts of age on white matter microstructure that were more pronounced in those with AUD. Plots of FA by age and group(s) in major white matter tracts may suggest a future need to explore higher order interactions in larger samples.
CONCLUSIONS These results bolster recent findings of similar microstructural properties in men and women with AUD but provide further rationale for the consideration of age when investigating impacts of chronic alcohol use on the brain's white matter.