APA
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Lee, M. R., Shin, J.-H., Deschaine, S., Daurio, A., Stangl, B., Yan, J., … Leggio, L. (2020). A role for the CD38 rs3796863 polymorphism in alcohol and monetary reward: evidence from CD38 knockout mice and alcohol self-administration, [11C]-raclopride binding, and functional MRI in humans. The American Journal of Drug and Alcohol Abuse.
Chicago/Turabian
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Lee, Mary R., Jung-Ho Shin, S. Deschaine, A. Daurio, B. Stangl, J. Yan, V. Ramchandani, et al. “A Role for the CD38 rs3796863 Polymorphism in Alcohol and Monetary Reward: Evidence from CD38 Knockout Mice and Alcohol Self-Administration, [11C]-Raclopride Binding, and Functional MRI in Humans.” The American journal of drug and alcohol abuse (2020).
MLA
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Lee, Mary R., et al. “A Role for the CD38 rs3796863 Polymorphism in Alcohol and Monetary Reward: Evidence from CD38 Knockout Mice and Alcohol Self-Administration, [11C]-Raclopride Binding, and Functional MRI in Humans.” The American Journal of Drug and Alcohol Abuse, 2020.
BibTeX Click to copy
@article{mary2020a,
title = {A role for the CD38 rs3796863 polymorphism in alcohol and monetary reward: evidence from CD38 knockout mice and alcohol self-administration, [11C]-raclopride binding, and functional MRI in humans},
year = {2020},
journal = {The American journal of drug and alcohol abuse},
author = {Lee, Mary R. and Shin, Jung-Ho and Deschaine, S. and Daurio, A. and Stangl, B. and Yan, J. and Ramchandani, V. and Schwandt, M. and Grodin, E. and Momenan, R. and Corral-Frías, N. and Hariri, A. and Bogdan, R. and Alvarez, V. and Leggio, L.}
}
ABSTRACT Background: Cluster of differentiation 38 (CD38) is a transmembrane protein expressed in dopaminergic reward pathways in the brain, including the nucleus accumbens (NAc). The GG genotype of a common single nucleotide polymorphism (SNP) within CD38, rs3796863, is associated with increased social reward. Objective: Examine whether CD38 rs3796863 and Cd38 knockout (KO) are associated with reward-related neural and behavioral phenotypes. Methods: Data from four independent human studies were used to test whether rs3796863 genotype is associated with: (1) intravenous alcohol self-administration (n = 64, 30 females), (2) alcohol-stimulated dopamine (DA) release measured using 11C-raclopride positron emission tomography (n = 22 men), (3) ventral striatum (VS) response to positive feedback measured using a card guessing functional magnetic resonance imaging (fMRI) paradigm (n = 531, 276 females), and (4) resting state functional connectivity (rsfc) of the VS (n = 51, 26 females). In a fifth study, we used a mouse model to examine whether cd38 knockout influences stimulated DA release in the NAc core and dorsal striatum using fast-scanning cyclic voltammetry. Results: Relative to T allele carriers, G homozygotes at rs3796863 within CD38 were characterized by greater alcohol self-administration, alcohol-stimulated dopamine release, VS response to positive feedback, and rsfc between the VS and anterior cingulate cortex. High-frequency stimulation reduced DA release among Cd38 KO mice had reduced dopamine release in the NAc. Conclusion: Converging evidence suggests that CD38 rs3796863 genotype may increase DA-related reward response and alcohol consumption.